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Figure 1 | Virology Journal

Figure 1

From: Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain

Figure 1

Anti-DENV group I intron targeting and trans-splicing DENV targets. Illustration of the anti-DENV group I intron, αDENV-U143, targeting the DENV genome and the associated trans-splicing reaction. The targeted 5’ CS domain of the DENV genome is conserved among all serotypes [18]. The uracil at position 143, located within the 5’ CS domain, is targeted for cleavage. Ribozyme and target DENV genomic (blue) RNAs are indicated. IGS = Internal guide sequence, EGS = external guide sequence, CS = cyclization sequence.

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Virology Journal

ISSN: 1743-422X