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Figure 3 | Virology Journal

Figure 3

From: Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model

Figure 3

Analysis of the effect of NTZ on JEV replication in BHK-21 cells. BHK-21 cells were infected with JEV at a MOI of 0.001 and treated with NTZ at the indicated concentrations. (A) The cells were incubated for 48 h and harvested for virus titration. The reduction in virus titer was calculated and plotted. The x-axis is in a base 2 logarithmic scale. (B) The JEV-infected cells were treated with NTZ at 3 μg/ml and incubated for the indicated times. The virus titers in the cells and supernatants were determined by a plaque assay, respectively. (C) The JEV-infected cells were treated with NTZ at 3 μg/ml and incubated for the indicated times. The number of RNA copies of viral C gene in the cells was determined by qRT-PCR. The data are means with SD from three independent experiments. *, p < 0.05 compared with the DMSO-treated cells. hpi, hours post-infection.

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Virology Journal

ISSN: 1743-422X