Table 3 Main HBs amino-acid changes observed in treated and untreated patients
HBs amino-acid changes | Overall | HBV active treatment | p | ||
|---|---|---|---|---|---|
Never | Ongoing | Stopped | |||
Y100 | 10 (4.9%) | 1 (2.6%) | 5 (4.6%) | 4 (7.0%) | 0.59 |
S114 | 113 (52.6%) | 16 (41.0%) | 60 (53.7%) | 37 (58.7%) | 0.22 |
T118 | 6 (2.7%) | 1 (2.5%) | 4 (3.4%) | 1 (1.5%) | 0.75 |
T125 | 27 (12.4%) | 4 (10.3%) | 15 (13.2%) | 8 (12.3%) | 0.89 |
T126 | 3 (1.4%) | 0 | 1 (0.9%) | 2 (3.1%)0 | 0.33 |
P127 | 71 (32.7%) | 19 (50.0%) | 34 (29.6%) | 18 (28.1%) | 0.04 |
T131 | 131 (59.5%) | 16 (41%) | 75 (64.1%) | 40 (62.5%) | 0.03 |
M133 | 4 (1.8%) | 1 (2.5%) | 3 (2.6%) | 0 | 0.427 |
Y134 | 170 (78.3%) | 34 (85.0%) | 82 (73.2%) | 54 (83.1%) | 0.16 |
T140 | 51 (23.1%) | 16 (41.0%) | 21 (17.9%) | 14 (21.5%) | 0.012 |
S143 | 116 (53%) | 15 (38.5%) | 63 (55.3%) | 38 (59.4%) | 0.10 |
D144 | 5 (2.3%) | 2 (5.0%) | 3 (2.7%) | 0 | 0.24 |
G145 | 6 (2.8%) | 1 (2.6%) | 5 (4.3%) | 0 | 0.25 |