Figure 3

RAL Linear models. ( A) In the clonal genotype-phenotype database, fifty mutations were retained with frequency > 10% in the GA models. Stepwise regression was used for building a first order linear regression model and a second order linear regression model. (B) First order linear regression model. (C) Second order linear regression model. In ( B) and (C) primary and secondary mutations are indicated according to the drug label (upper left corner) and prevalence in GA models is shown (upper right corner). Colouring is based on the FC contribution of the mutations/interaction pairs in the linear regression model: >0.1-2 (green), >2-10 (yellow), >10 (red). *Introduced as site-directed mutant in the model: 66K, 121Y and 155S.