Figure 9

Pathology of virus infected lung, liver and brain tissues. Adult or 2 day old suckling mice were infected intranasaly with 10⁷ or 10⁵ pfu respectively with either T1L or T3D before sectioning formalin fixed, paraffin embedded sections for histopathological assessment by H and E. staining. Panels a, d, g, and j show uninfected control images for adult or suckling lung, liver and brain sections of mice as labeled. Panels b, e, h, and k show the T1L infected lung, liver and brain of the indicated types (suckling or adult) of infected mouse organs. Panels c, f, i, and l show the T3D infected lung, liver and brain for the indicated types (suckling or adult) of mouse organs. Arrows show local areas of cellular damage in liver and suckling brain sections that show the dentate gyrus of the hippocampus. Lungs and liver were imaged 7 days pi and brains at 13 days pi. Images were captured with the 20X objective.