Figure 3

Modulation of immune response-associated genes by CPXV, MPXV or VACV infection. An overview of the changes in host gene expression patterns of immune response-associated genes induced by all three different OPV. Folds of change in gene expression in comparison to mock-infected cells are represented as gradient red and green colour representing low and high relative expression in the respective microarray (shown are 2 arrays per virus). Numbers indicate the log10 of the change fold values. GO term assignment of the respective genes is displayed by different colours. Red = “leukocyte activation”, green = “regulation of leukocyte activation”, blue = “leukocyte migration”, magenta = “regulation of leukocyte migration”, yellow = “human chemokine activity”, turquoise = “inflammatory response”. Only those genes are shown which had at least a 2-fold change in expression relative to the mock-infected control and for which the direction of regulation detected by both arrays was the same. Additionally, regulation in each selected gene differs by a factor of at least 2 between at least two of the samples.