CPXV- and MPXV- but not VACV-modulated cellular pathways are involved in infectious diseases. Cellular pathways that were significantly affected by infection with CPXV, MPXV or VACV, respectively, as indicated by * (p ≤ 0.05) or ** (p ≤ 0.01). Along with pathways which describe general processes of the cell, we identified several immune system-specific pathways (A) and several pathways which are specific to certain diseases (B). P-values indicate the probability of random association between the genes in the data set and the canonical pathway. Abbreviations used in the figure: C-CR interaction = cytokine–cytokine receptor interaction; Transcr. misreg. in cancer = transcriptional misregulation in cancer.