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Table 2 Dynamics of well-known protease inhibitor resistance mutations in the viral NS3 protease gene over time from patients infected with the Hepatitis C virus

From: Dynamics of resistance mutations to NS3 protease inhibitors in a cohort of Brazilian patients chronically infected with hepatitis C virus (genotype 1) treated with pegylated interferon and ribavirin: a prospective longitudinal study

Treatment Time Patient ID
(Genotype – Treatment response – Mutation)
PEG-IFN/RBV Pat A Pat B Pat C
(1b – SVR – T54S) (1a – REL – V36L/V55A) (1a – NR –T54S)
Before   T 36L/55A S
During 48 h T* 36L/55A S
  7d S** 36L/55A S
  30d *** *** S
  3 m - *** S
  6 m - - S
  12 m - - Nb
After 18 m - 36L/55A Nb
  1. SVR, Sustained Virological Responder; REL, Relapsing; NR, Non-Responder, -, Undetectable HCV RNA; Nb, No blood was collected. h, hours; d, days; m, months.
  2. Viral loads ranged from 4 × 104 to 4 × 106 unless indicated by *. Viral load: * 7.0 × 102, ** 2.6 × 103, and *** <500 IU/ml.