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Table 8 Clinical features of different antibody combinations in EBV-positive patients (age ≥8 months)

From: The impact of serological features in Chinese children with primary or past Epstein–Barr virus infections

Clinical features A (n = 17) B (n = 8) C (n = 13) D (n = 112) E (n = 121)
Length of stay (days) 10.5 ± 2.9* 10.4 ± 4.9 9.0 ± 4.5 8.0 ± 2.9* 9.1 ± 4.0
Fever 17 (100.0%) 8 (100.0%) 12 (92.3%) 100 (89.3%) 106 (87.6%)
Cough 9 (52.9%) 8 (100.0%) 12 (92.3%) 79 (70.5%) 90 (74.4%)
Rash 4 (23.5%) 4 (50.0%) 0 (0.0%) 23 (20.5%) 19 (15.7%)
Lymphadenopathy 11 (64.7%)** 6 (75.0%) 5 (38.5%) 41 (36.6%) 35 (28.9%)*
Pharyngitis 16 (94.1%) 7 (87.5%) 10 (76.9%) 89 (79.5%) 87 (71.9%)
Palatal petechiae 9 (52.9%)** 2 (25.0%) 5 (38.5%) 20 (17.9%)* 24 (19.8%)
Abnormal chest X ray 8/9 (88.9%) 2/2 (100.0%) 3/5 (60.0%) 50/57 (87.7%) 53/65 (81.5%)
Bronchitis (X ray) 3/9 (33.3%) 1/2 (50.0%) 2/5 (40.0%) 32/57 (56.1%) 25/65 (38.5%)
Pneumonia (X ray) 5/9 (55.6%) 1/2 (50.0%) 1/5 (20.0%) 18/57 (31.6%) 28/65 (43.1%)
Hepatomegaly 5 (29.4%) 2 (25.0%) 3 (23.1%) 7 (6.3%) 11 (9.1%)
Splenomegaly 4 (23.5%) 0 (0.0%) 1 (7.7%) 7 (6.3%) 5 (4.1%)
ALC >10% 12/15 (80.0%)** 0/6 (0.0%)* 4/8 (50.0%) 14/66 (21.2%)* 18/77 (23.4%)*
Elevated ESR 8/14 (57.1%) 5/6 (83.3%) 2/10 (20.0%) 43/81 (53.1%) 31/66 (47.0%)
Elevated CRP 4/13 (30.8%) 5/6 (83.3%) 5/9 (55.6%) 42/83 (50.6%) 43/76 (56.6%)
ALF 9/13 (69.2%) 1/4 (25.0%) 2/6 (33.3%) 9/36 (25.0%) 15/38 (39.5%)
  1. A: patients with the antibody combination of [VCA-IgM+, VCA-IgG– and EBNA-IgG–]. B: patients with the antibody combination of [VCA-IgM+, VCA-IgG+ and EBNA-IgG+]. C: patients with the antibody combination of [VCA-IgM–, VCA-IgG+ and EBNA-IgG–]. D: patients with the antibody combination of [VCA-IgM–, VCA-IgG+ and EBNA-IgG+]. E: patients with the antibody combination of [VCA-IgM–, VCA-IgG– and EBNA-IgG–]. ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ALC, atypical lymphocytes; ALF, abnormal liver function (alanine aminotransferase or aspartate aminotransferase levels >46 U/L). P < 0.05 between * and **.