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Figure 3 | Virology Journal

Figure 3

From: An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity

Figure 3

Survival of macaques after SIV-infection and ML29 vaccination. Eleven of 16 rhesus macaques that had been infected with SIVmac survived to be enrolled in a ML29 vaccination study (day 393 after SIV infection). Macaques were classified as rapid (>106 SIV RNA mol/ml at setpoint), median (104 – 106 RNA mol/ml), and slow (<104 RNA mol/ml) AIDS progressors. Eight were vaccinated with ML29 and three were given LCMV-Armstrong, and all were monitored for signs of arenavirus disease. Five months after vaccination, 5 healthy animals remained, having survived 530 days after SIV infection. The absence of gross signs of arenavirus disease and the absence of clinical signs in blood and tissues samples indicated that vaccinated animals were protected from arenavirus disease.

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