Vaccine | NT titer to | Virus titer in lungs, mean log PFU/g ±Sea | |||
---|---|---|---|---|---|
Strain | Protein, μg | Formulation | Narita/09 | Sw/Hok/81 |  |
PBS | - | - | <10, <10, <10, <10, <10 | <10, <10, <10, <10, <10 | 5.0±0.17 |
Narita/09 | 4 | ES | <10, <10, <10, <10, <10 | ND | 4.6±0.10 |
 | 20 | ES | <10, 20, 20, 20, 40 | ND | 4.6±0.12 |
 | 100 | ES | 20, 40, 80, 160, 160 | ND | 4.1±0.35 |
Narita/09 | 4 | WV | 40, 40, 40, 80, 160 | ND | 4.2±0.17 |
 | 20 | WV | 40, 80, 160, 160, 320 | ND | 3.9±0.25* |
 | 100 | WV | 320, 320, 640, 1280, 1280 | ND | 2.4±0.50** |
Sw/Hok/81 | 4 | ES | <10, <10, <10, <10, <10 | <10, <10, <10, 10, 10 | 4.6±0.04 |
 | 20 | ES | <10, <10, <10, <10, <10 | <10, 10, 10, 20, 80 | 4.4±0.02 |
 | 100 | ES | <10, <10, <10, <10, <10 | 10, 20, 20, 40, 40 | 4.7±0.02 |
Sw/Hok/81 | 4 | WV | <10, <10, <10, <10, <10 | 20, 40, 40, 40, 80 | 4.5±0.06 |
 | 20 | WV | <10, <10, <10, <10, <10 | 20, 40, 80, 80, 80 | 4.4±0.04 |
 | 100 | WV | <10, <10, <10, <10, <10 | 160, 160, 160, 160, 320 | 4.3±0.09 |