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Table 3 Non-synonymous substitutions* detected in 5 samples with 222 variants (INER047, INER264, INER306, INER307 and INER405)

From: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico

Gene

Substitution

Subject:

  

INER047

INER306

INER405

INER264

INER307

PB1

V587G

X

X

X

 

X

 

A652V

X

X

X

X

X

PB2

E191G

 

X

   
 

Q194H

X

X

X

X

X

PA

P224S

X

X

X

X

X

 

A307G

X

    
 

S395R

 

X

   
 

P434L

 

X

   
 

V521I

  

X

  
 

I573Y

  

X

  

NP

S69P

   

X

X

 

V100I

X

X

X

X

X

 

T373I

   

X

 

NA

V106I

X

X

X

X

X

 

N248D

X

 

X

  
 

V304A

    

X

 

T381N

 

X

 

X

X

M1

I24V

 

X

   
 

S30R

   

X

 
 

H222N

X

    

NS2

Q20R

 

X

X

X

X

 

L58F

X

    
 

L120F

 

X

X

X

X

NS1

V65M

  

X

  
 

L95P

 

X

X

X

X

 

I123V

X

X

X

X

X

 

I128T

X

    
 

V180I

 

X

X

 

X

 

L181F

   

X

 
 

P215L

X

    

HA**

N27D

 

X

   
 

N48D

 

X

X

 

X

 

V169I

 

X

   
 

G172R

X

X

 

X

 
 

S179N

 

X

X

 

X

 

W194R

   

X

 
 

A203T

 

X

X

X

X

 

T214A

X

X

X

X

X

 

I338V

X

X

X

X

X

 

Y528C

   

X

 
  1. * Sequences used for comparison were from Influenza A virus (A/California/04/2009(H1N1)) accession number GQ280797.1.
  2. ** HA positions are given without removing the signal peptide.
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Virology Journal

ISSN: 1743-422X