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Figure 5 | Virology Journal

Figure 5

From: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico

Figure 5

Immunohistochemical detection of influenza A specific antigen (NP) in mice infected with various strains of H1N1 at 5 dpi. A. Lung from an animal infected with strain INER405 (also representative of INER307 infection) showing detection of viral antigen in bronchiolar epithelial cells (arrowhead) and occasionally in cells within alveolar walls (arrows). Bar = 50μm B. Lung from an animal infected with strain INER111 showing viral antigen within bronchiolar epithelium (arrowhead) as well as extensively within alveolar walls (arrows). Bar = 50μm C. Viral antigen could be detected extensively throughout areas of consolidation (arrows) in an animal infected with strain INER047. Bar = 50 μm. D. Immunohistochemistry for influenza A specific antigen (NP) on lung from a non-infected control animal. Bar = 100μm.

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