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Figure 3 | Virology Journal

Figure 3

From: A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico

Figure 3

Pathogenicity of pdm09 isolates in mice. A) Cumulative survival curves in mice after intranasal inoculation with different viruses isolated from hospitalized patients are shown. Three mice per group were inoculated with different viruses: INER307 (D222), INER047 (G222:N222, 19:1), INER111 (G222) and INER405 (G222). Mice were monitored for 14 days. B) Mean body weight and observations in mice infected intranasally with 5.5 TCID 50 of viruses isolated from hospitalized patients. Body weight losses were determined daily up to day 14 after inoculation. C) Viral titer were determined by TCID50 in lung homogenates of mice infected by viruses from the hospitalized patients.

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