Figure 3From: Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from KeralaComparative amino acid sequence analysis of the Capsid-PrM-Envelope region of DENV-3 strains. The amino acid sequences derived from the nucleotide sequences of the capsid, pre-membrane and envelope coding region of the NCBI reference strain (NC_001475), viral strains from Kerala and other closely related Indo-Pacific strains were aligned using Clustal W and compared. The domains and structural features were located in the aligned sequences based on the previous report [31] and they are indicated in the figure. The signature amino acid substitution T219A in lineage IV strains newly identified in the study is shown with an arrow.Back to article page