Table 1 Cellular factors cleaving Tat ( http://www.ncbi.nlm.nih.gov/projects/RefSeq/HIVInteractions/ )
From: Roles and functions of HIV-1 Tat protein in the CNS: an overview
Protein name | Protein Acc | Ref PMID | Interaction description |
|---|---|---|---|
Calpain-1 catalytic subunit | NP_005177.2 | 19022302 | Calpain-mediated cleavage of HIV-1 Tat occurs in the C-terminus of this viral protein, between amino acids 68 and 69. The cleavage of Tat by calpain 1 increases neurotoxic effect of this viral protein |
Furin preproprotein | NP_002560.1 | 15135058 | Furin cleaves HIV-1 Tat at amino acid residue 56, resulting in greatly reduced Tat transactivation activity |