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Table 1 Cellular factors cleaving Tat ( http://www.ncbi.nlm.nih.gov/projects/RefSeq/HIVInteractions/ )

From: Roles and functions of HIV-1 Tat protein in the CNS: an overview

Protein name Protein Acc Ref PMID Interaction description
Calpain-1 catalytic subunit NP_005177.2 19022302 Calpain-mediated cleavage of HIV-1 Tat occurs in the C-terminus of this viral protein, between amino acids 68 and 69. The cleavage of Tat by calpain 1 increases neurotoxic effect of this viral protein
Furin preproprotein NP_002560.1 15135058 Furin cleaves HIV-1 Tat at amino acid residue 56, resulting in greatly reduced Tat transactivation activity