Table 1 Clinical description and outcome of Nipah virus challenged ferrets
Group-subject no. | Clinical illnessa | Viralbload | Clinical and gross pathology |
|---|---|---|---|
1-1 | Fever (d5-7); Depression (d6-7); lethargy (d6-7); loss of appetite (d6-7); labored breathing (d6-7). Animal euthanized on d7. | ++/6, ++/7 | Thrombocytopenia (d7); Lymphopenia (d6-7); >3-fold increase in BUN (d7); rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver, edema of left kidney capsule. |
1-2 | Fever (d5); depression (d6-8); lethargy (d6-8) loss of appetite (d6-8); labored breathing (d6-8); dehydration (d8), ocular and nasal discharge (d7-8); Hind limb paresis (d8) Animal euthanized on d8. | ++/6, ++/8 | Thrombocytopenia (d8); Lymphopenia (d6,8); >3-fold increase in BUN (d8); hypoalbuminemia (d6,8); ecchymotic rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver. |
1-3 | Fever (d4-7); depression (d5-7); lethargy (d5-7); loss of appetite (d5-7); labored breathing (d6-7); ocular and nasal discharge (d6-7); Hind limb paresis (d7). Animal euthanized d7. | ++/6, ++/7 | Thrombocytopenia (d6-7); Lymphopenia (d6-7); hypoalbuminemia (d6-7); ecchymotic rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver. |
1-4 | Fever (d5-7); Depression (d6-8); lethargy (d7-8); loss of appetite (d6-8); labored breathing (d6-8); hind limb tremors (d8). Animal euthanized on d8. | ++/6, ++/8 | Thrombocytopenia (d8); Lymphopenia (d6,8); hypoalbuminemia (d8); lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver. |
1-5 | Fever (d5-7); Depression (d6-7); lethargy (d7); loss of appetite (d5-7); dehydration (d7); labored breathing (d6-7). Animal euthanized on d7. | ++/6, ++/7 | Thrombocytopenia (d7); Lymphopenia (d6-7); hypoalbuminemia (d7); lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver. |
2-1 | None | Â | None |
2-2 | None | +/6 | None |
2-3 | None | Â | None |
2-4 | None | Â | None |
2-5 | Mild fever (d7) | +/6 | None |
3-1 | None | Â | None |
3-2 | None | Â | None |
3-3 | None | +/6 | None |
3-4 | None | Â | None |
3-5 | None | +/6 | None |
4-1 | None | Â | None |
4-2 | None | Â | None |
4-3 | None | +/6 | None |
4-4 | None | +/6 | None |
4-5 | None | Â | None |