Figure 5

H&E and immunohistochemistry of ferret tissues. Representative H&E stained tissues (A , C , E, G, I, K, M, and O) and immuno-histochemistry of tissues labeled with a NiV N protein-specific polyclonal rabbit antibody (B, D, F, H, J, L, N, and P). Tissues from representative vaccinated ferrets from groups 2-4; lung (A, B), spleen (E, F), kidney (I, J), and brain, choroid plexus (M, N). Tissues from representative control Group 1 ferrets; lung (C, D), spleen (G, H), kidney (K, L), and brain, choroid plexus (O, P). C, (arrow head) Respiratory epilthelial syncytia; D, (arrow) NiV antigen-positive respiratory epithelial syncytia, G, (white asterisk) lymphoid depletion in spleen; K, (*) fibrin deposition in glomerular tuft of kidney. Images taken: lung 40x, spleen 20x, kidney 40x, brain 40x.