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Table 1 Subject clinical details

From: Stable HIV-1 integrase diversity during initial HIV-1 RNA Decay suggests complete blockade of plasma HIV-1 replication by effective raltegravir-containing salvage therapy

Subject

DS1

DS2

DS3

DS4

Gender

Male

Male

Male

Female

Age

61

39

49

44

Date of diagnostic

13/05/96

01/01/90

01/07/87

01/01/91

Transmission type

Heterosexual

IVDU

IVDU

IVDU

Previous ART lines

9

6

12

12

#drugs before RAL

13

9

13

12

New drugs started alongside RAL

DRV

DRV

DRV,ETV, T-20

DRV,MVC

Previous exposure

    

NRTI

YES

YES

YES

YES

NNRTI

YES

YES

YES

YES

PI

YES

YES

YES

YES

T-20

NO

NO

NO

NO

ART

ddI + 3TC + DRV/r + RAL

TDF/FTC + DRV/r + RAL

TDF/FTC + DRV/r + RAL + T-20

DRV/r + RAL + MVC

GSS

4

3.5

3.5

3.5

Baseline CD4 (cells/mm 3)

614

300

332

399

  1. Intravenous Drug Use (IVDU); Genotypic Sensitivity Score (GSS, Stanford HIVdb), NRTI: Nucleoside-analogues Reverse Transcriptase Inhibitor; NNRTI non- Nucleoside-analogues Reverse Transcriptase Inhibitor; PI: Protease Inhibitor; Darunavir (DRV); Didanosine (DDI); Lamivudine (3TC); Raltregravir (RAL); Ritonavir (RTV); Emtricitabine (FTC); Tenofovir (TDF); Etravirine (ETV); Enfuvirtide (T-20); Maraviroc (MVC).