Longitudinal evolution of integrase polymorphisms relative to Consensus B. Each plot corresponds to one subject. Integrase polymorphisms are in the vertical axis. The horizontal axis shows the different longitudinal timepoints assessed during the initial HIV-1 RNA load decay. The frequency of each polymorphism is represented using a color scale, from 100% (dark red) to a 1.0% threshold (light blue). White indicates non detection of polymorphisms. A remarkable stability in polymorphism type and frequency is observed. Of note, none of the IAS-list (2013) integrase resistant mutations were found.