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Table 1 All sites with scaled Bayes factors ≥ 6

From: Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Serum HXB2 position Reference residue Scaled Bayes factor (LFDR) Backbone ID50fold effect
CAP256 166 Arg 25.4 (0.0001) CAP45 261.3*
     ConC 22.2*
  169 Lys 10.7 (0.083) CAP45 365.8*
     ConC 15.3*
CAP8 24 Met 6.4 (1.000)   NT
  295 Asn 11.9 (1.000) TRO 0.4
  316 Thr 9.1 (1.000) ConC 1.8
  535 Ile 6.0 (1.000)   NT
CAP257 166 Arg 6.3 (0.738) ConC 1.8
  295 Asn 7.0 (0.665) Q842 0.1
  648 Glu 6.1 (0.757) Du156 1.2
     RHPA 2.9*
  702 Leu 6.2 (0.747)   NT
CAP255 332 Asn 8.0 (0.622) Q23 4.0*
     TRO 2.9*
     ConC 0.2
  334 Ser 6.8 (0.750) TRO >12.4*
     ConC 0.3
  351 Glu 6.8 (0.750)   NT
  837 Phe 10.1 (0.366)   NT
CAP177 209 Thr 8.8 (0.388) TRO 0.4
  332 Asn 7.3 (0.573) ConC 1.7
     Q23 11.0*
     TRO >2.8*
  334 Ser 7.8 (0.511) ConC 2.1*
     TRO 0.2
  683 Lys 6.3 (0.689)   NT
CAP206 150 Met 6.7 (0.457)   NT
  655 Lys 7.3 (0.384)   NT
CAP248 85 Val 6.5 (1.000)   NT
  340 Glu 6.0 (1.000) ConC 2.2*
     CAP45 0.6
  651 Asn 7.4 (1.000) ConC 2.0*
     CAP45 1.3
     Du156 2.4*
  659 Asp 8.9 (1.000) ConC 2.9*
     CAP45 0.5
  1. Sites with q ≤ 1/3 based on the method of Gnanakaran et al. [15]. Amino acid found to be significantly enriched among sensitive (high titer) viruses based on our evolutionary model. *Fold effect ≥ 2. NT = Not tested.