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Table 1 All sites with scaled Bayes factors ≥ 6

From: Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Serum

HXB2 position

Reference residue‡

Scaled Bayes factor (LFDR)

Backbone

ID50fold effect

CAP256

166†

Arg

25.4 (0.0001)

CAP45

261.3*

    

ConC

22.2*

 

169†

Lys

10.7 (0.083)

CAP45

365.8*

    

ConC

15.3*

CAP8

24

Met

6.4 (1.000)

 

NT

 

295

Asn

11.9 (1.000)

TRO

0.4

 

316†

Thr

9.1 (1.000)

ConC

1.8

 

535

Ile

6.0 (1.000)

 

NT

CAP257

166

Arg

6.3 (0.738)

ConC

1.8

 

295

Asn

7.0 (0.665)

Q842

0.1

 

648

Glu

6.1 (0.757)

Du156

1.2

    

RHPA

2.9*

 

702

Leu

6.2 (0.747)

 

NT

CAP255

332

Asn

8.0 (0.622)

Q23

4.0*

    

TRO

2.9*

    

ConC

0.2

 

334

Ser

6.8 (0.750)

TRO

>12.4*

    

ConC

0.3

 

351

Glu

6.8 (0.750)

 

NT

 

837

Phe

10.1 (0.366)

 

NT

CAP177

209

Thr

8.8 (0.388)

TRO

0.4

 

332†

Asn

7.3 (0.573)

ConC

1.7

    

Q23

11.0*

    

TRO

>2.8*

 

334†

Ser

7.8 (0.511)

ConC

2.1*

    

TRO

0.2

 

683

Lys

6.3 (0.689)

 

NT

CAP206

150

Met

6.7 (0.457)

 

NT

 

655

Lys

7.3 (0.384)

 

NT

CAP248

85

Val

6.5 (1.000)

 

NT

 

340

Glu

6.0 (1.000)

ConC

2.2*

    

CAP45

0.6

 

651

Asn

7.4 (1.000)

ConC

2.0*

    

CAP45

1.3

    

Du156

2.4*

 

659

Asp

8.9 (1.000)

ConC

2.9*

    

CAP45

0.5

  1. †Sites with q ≤ 1/3 based on the method of Gnanakaran et al. [15]. ‡Amino acid found to be significantly enriched among sensitive (high titer) viruses based on our evolutionary model. *Fold effect ≥ 2. NT = Not tested.