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Figure 5 | Virology Journal

Figure 5

From: Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Figure 5

Bayesian evolutionary-network model for CAP255 [[38]]. The red node corresponds to ID50 titer and all other nodes represent sites in the HIV-1 envelope. Nodes with scaled Bayes factors > 6 are shaded in dark green, while nodes with scaled Bayes factors between 2 and 6 are shaded in light green. An edge connecting two nodes indicates that there is a direct association between the two nodes. Edges are labeled with the estimated posterior probability of an interaction between the nodes they connect. Only sites with scaled Bayes factors > 4 or posterior probabilities of an association with such a site > 0.75 are shown. Since all of the sites with Bayes factors > 4 are directly connected to the ID50 node, none of the predicted associations could be attributed to compensatory mutations.

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