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Figure 5 | Virology Journal

Figure 5

From: Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus

Figure 5

PFA-inactivated HTLV-1+T cells inhibit infection of activated autologous PBMCs with R5 HIV-1, but not X4 HIV-1, via OX40L and β-chemokines. In vitro activated PBMCs were infected with either R5 HIV-1 (JR-FL strain) or X4 HIV-1 (NL4-3 strain) and cultured in the presence or absence of recombinant OX40L, PFA-inactivated autologous HTLV-1+ T cells, anti-OX40L blocking mAb (5A8) or a mixture of anti-β-chemokine neutralizing mAbs. After 4 days, the cells were examined for intracellular HIV-1 p24 by FCM. Data shown are representative of 3 independent experiments.

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Virology Journal

ISSN: 1743-422X