Figure 3

Gross and histological images of tree shrew no. A1. A. The surface of the liver is coarsely nodular with multifocal mottled tan and red areas. B. Megalocytosis. HE staining, 200× and 400× respectively. C. Piecemeal necrosis (arrow) characterized by lymphocytic infiltration extends from portal areas and disrupts the limiting plate of hepatocytes undergoing necrosis. HE staining, 100×. D. Bridging necrosis as a streak of hepatic necrosis extends from central vein (C) to portal tracts (P). HE staining, 40×. E. Reticular fiber collapses and intertwines to form a cluster (arrow) in limiting plate. Gomori’s silver staining, 200× and 400× respectively. F. There is increased collagen in portal areas. Masson staining, 200×.