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Table 2 Amino acid substitution in the variable region and neutralizing epitopes of the F-gene sequences of the Japanese field strains

From: Molecular epidemiology of Newcastle disease virus isolates from vaccinated commercial poultry farms in non-epidemic areas of Japan

  Hypervariable region Neutralizing epitopes
Virus 4 10 11 13 20 21 27 52 63 78 93 101 121 72 74 75 78 79 157-171 343
Consensusa K P A L M L C I V K T R V D E A K A SIAATNEAVHEVT L
JP/Osaka/2440/1969 -b - V - - - - - - - - - - - - - - - - -
JP/Ibaraki/SM87/1987 - L V P T - - - I - S - I - - - - - - -
JP/Ibaraki/SG106/1999 I - - - - P R V - R - K - - - - R - - -
JP/Chiba/BY103/2001 I - - - - P R V - R - K - - - - R - - -
JP/Ibaraki/IS5/2002 I - - - - P R V - R - K - - - - R - - -
JP/Ibaraki/IS2/2002 I - - - - P R V - R - K - - - - R - - -
JP/Miyagi/AGT/2002 I - - - - P R V - R - K - - - - R - - -
JP/Chiba/BY7/2002 I - - - - P R V - R - K - - - - R - - -
JP/Fukushima/NYF3/2002 I - - - - P R V - R - K - - - - R - - -
JP/Sato/30 R - - - A - H - - - - - I - - - - - n.d. n.d.
US/B1/47 R - - M A - - - - - - - I - - - - - - -
LaSota/46 R - - M A - - - - - - - I - - - - - - -
JP/Ishii/62 R - V - V - - - - - - - I - - - - - - -
  1. aThe consensus amino acid sequence was derived from 100–180 velogenic, mesogenic and lentogenic NDV strains from GenBank; bSame as consensus sequence.