Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats

Harun, Mohammad Syamsul Reza; Kuan, Choong Oi; Selvarajah, Gayathri Thevi; Wei, Tan Sheau; Arshad, Siti Suri; Bejo, Mohd Hair; Omar, Abdul Rahman

doi:10.1186/1743-422X-10-329

Virology Journal

Table 1 List of top 20 up regulated genes and their functions

From: Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats

No.	Fold change	BLAST result	Accession number	Gene product function
1**	∞/ ∞	CCL8	S 67956	induce Th cytokinesattract monocyte, lymhpocyte, NK cell, dendritic cell, basophil & eosinophil
2*	22.8/ 19.33	RSAD2	XM_ 002921192	ISG, inhibit viral protein & RNA synthesis
3*	12.98/ 7.64	CXCL10	XM_ 002924730	induce Th1 cells response stimulate monocyte, NK & T cell migration
4*	12.73/ 11.36	SLAMF7	XM_ 002928442	stimulate NK cell cytotoxicity, B cell growth, promote lymphocytes adhesion
5	6.68	FSTL3	XM_ 850129	regulate cell to cell adhesion
6*	6.11/ 2.34	ATF3	XM_ 847382	promote apoptosis and cell proliferation, promotes Th1 and NK cells activity
7*	6.04/ 4.68	MFSD2A	AL 663070	regulate cell growth, cell adhesion & motility
8	5.76	ESE1	XM_ 002914595	regulate inflammation & cell differentiation
9**	5.65/ 4.07	A3C & A3H	EU 109281	ISG, antiviral cytidine deaminase, edit viral RNA/DNA causing mutation
10**	5.35/ 4.48	MDA5	NG_ 011495	ISG, viral RNA sensor induce cytokines and interferons
11*	4.96/ 3.00	IFI35	XM_ 002930054	ISG, inhibit viral gene transcription
12*	4.46/ 3.90	TRIM25	XM_ 548223	ubiquitination of RIG-I and ISG15 induce type I IFN
13*	4.46/ 4.34	MX1	NM_ 001003134	ISG, induce apoptosis in virus infected cells
14**	4.24/ 3.29	PD-L1	EU 246348	negative regulation of immune response, induce IL-10
15*	4.10/ 3.31	PHF11	AL 139321	Th1 cytokines activation
16**	3.98/ 3.54	RUNTX1	NG_ 011402	regulate gene transcription for T cell differentiation and function
17**	3.79/2.85	BHLHE40	XM_ 002919988	regulate gene transcription, lymphocyte activation & cell cycle and cell death
18*	3.69/ 3.56	HERC5	XM_ 002913599	ubiquitination of ISG15 and RIG-I
19	3.69	CCL17	NM_ 001009849	activate T cell development and maturation
20	3.65	DTX3L	XM_ 002927235	protect cell from DNA damage

*Two transcripts were found from the same gene.
**Two transcripts from the same gene with similar E-value, score and gaps.

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ISSN: 1743-422X

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