Skip to main content

Table 1 List of top 20 up regulated genes and their functions

From: Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats

No. Fold change BLAST result Accession number Gene product function
1** ∞/ ∞ CCL8 S 67956 induce Th cytokinesattract monocyte, lymhpocyte, NK cell, dendritic cell, basophil & eosinophil
2* 22.8/ 19.33 RSAD2 XM_ 002921192 ISG, inhibit viral protein & RNA synthesis
3* 12.98/ 7.64 CXCL10 XM_ 002924730 induce Th1 cells response stimulate monocyte, NK & T cell migration
4* 12.73/ 11.36 SLAMF7 XM_ 002928442 stimulate NK cell cytotoxicity, B cell growth, promote lymphocytes adhesion
5 6.68 FSTL3 XM_ 850129 regulate cell to cell adhesion
6* 6.11/ 2.34 ATF3 XM_ 847382 promote apoptosis and cell proliferation, promotes Th1 and NK cells activity
7* 6.04/ 4.68 MFSD2A AL 663070 regulate cell growth, cell adhesion & motility
8 5.76 ESE1 XM_ 002914595 regulate inflammation & cell differentiation
9** 5.65/ 4.07 A3C & A3H EU 109281 ISG, antiviral cytidine deaminase, edit viral RNA/DNA causing mutation
10** 5.35/ 4.48 MDA5 NG_ 011495 ISG, viral RNA sensor induce cytokines and interferons
11* 4.96/ 3.00 IFI35 XM_ 002930054 ISG, inhibit viral gene transcription
12* 4.46/ 3.90 TRIM25 XM_ 548223 ubiquitination of RIG-I and ISG15 induce type I IFN
13* 4.46/ 4.34 MX1 NM_ 001003134 ISG, induce apoptosis in virus infected cells
14** 4.24/ 3.29 PD-L1 EU 246348 negative regulation of immune response, induce IL-10
15* 4.10/ 3.31 PHF11 AL 139321 Th1 cytokines activation
16** 3.98/ 3.54 RUNTX1 NG_ 011402 regulate gene transcription for T cell differentiation and function
17** 3.79/2.85 BHLHE40 XM_ 002919988 regulate gene transcription, lymphocyte activation & cell cycle and cell death
18* 3.69/ 3.56 HERC5 XM_ 002913599 ubiquitination of ISG15 and RIG-I
19 3.69 CCL17 NM_ 001009849 activate T cell development and maturation
20 3.65 DTX3L XM_ 002927235 protect cell from DNA damage
  1. *Two transcripts were found from the same gene.
  2. **Two transcripts from the same gene with similar E-value, score and gaps.