Horizontal acquisition and a broad biodistribution typify simian foamy virus infection in a cohort of Macaca fascicularis

Table 6 SFV Pol amino acid sequences for five animals with long-term infection from colony CA5

			Amino acid position of SFV (Pol)
		Time Point*	781	788	790	795	797	799	801	802	813	821	829	847	853	856	857	865	866	870	902
	SFVmfa		N	N	K	D	K	M	E	R	A	A	G	R	V	Q	C	S	A	S	H
Detected sequence	A					E		I				T			T			A	T
	B							V		K		T			I			A
	C			H								T		K				A			Y
	D					E		I		K		T						A	T
	E		D					V		K		T						A
	F							V		K		T	R					A	T
	G			H						·		T	·			R		A		T
	H			H	R		R	F				T	·	·	·	·	·	A	·	·	·
Macaque	028GCE	1 (F)						V		K		T	R		I			A	T
	028GCE	2 (B)						V		K		T			I			A
	979BAC	1 (H)			R		R	F				T						A
	979BAC	2		H	R			F	K		T	T					Y	A	T
	049JI	1 (H)		H	R		R	F				T						A
	049JI	2		H	R		R	F				T	E	K				T
	357GH	1 (G)		H								T				R		A		T
	357GH	2 (G)		H								T				R		A		T
	980BAC	1 (H)		H	R		R	F				T						A
		2 (H)		H	R		R	F				T						A

Sequences are shown alongside the SFV M. fascicularis reference sequence, SFVmfa (Accession number AY686197) and the sequences identified in the colony (A-H) at the earliest time point. *, where appropriate, if the sequence is present elsewhere in the colony it is indicated in parentheses. The period between time points 1 and 2 is 67 months.

ISSN: 1743-422X