Skip to main content
Figure 3 | Virology Journal

Figure 3

From: Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses

Figure 3

Kaplan-Meier survival curves. Vaccinated and mock-vaccinated mice were challenged thorough the intra-vaginal route with 106 PFU of HSV-1 McKrae (A) or HSV-2(G) (B) 21 days post primary vaccination and observed for 14 days. Ninety percent of the vaccinated animals in the HSV-1 challenged group survived, while 90% of the mock-vaccinated animals died (A). A statistically significant difference was observed between the vaccinated and mock-vaccinated groups (p = 0.0002) using the Gehan-Breslow-Wilcoxin test. Among animals challenged with HSV-2(G), 70% of the vaccinated group survived while 100% of the mock-vaccinated animals died (B). A statistically significant difference was observed between the vaccinated and mock-vaccinated groups (p = 0.0001) using the Gehan-Breslow-Wilcoxin test.

Back to article page

Virology Journal

ISSN: 1743-422X