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Table 3 Pro-inflammatory cytokines secretion by vaginal keratinocytes after treatment for 24 h with extracts/n-butanol fraction prepared from stem bark of A. catechu

From: Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat

Treatment with plant extract/fraction*

Level of cytokines (pg/ml)

 

IL-8

IL-1β

IL-6

TNF

Control

282 ± 5.3

2.2 ± 0.2

118 ± 9.1

1.1 ± 0.6

Aqueous extract

248 ± 11.1

3.4 ± 0.2

115.0 ± 8.4

1.7 ± 0.1

50% Ethanolic extract

40.4 ± 3.9**

4.0 ± 0.0

34.8 ± 1.3#

1.7 ± 0.3

n-Butanol fraction

2.7 ± 0.6**

3.4 ± 0.3

8.8 ± 0.6#

1.8 ± 0.5

  1. *Various plant extracts/n-butanol fraction were used at 100 μg/ml.
  2. **p < 0.001 as compared to IL-8 concentration in the control group.
  3. #p < 0.001 as compared to IL-6 concentration in the control group.