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Table 1 Cytotoxicity and anti-HIV-1 activity of the extracts/n-butanol fraction of stem bark of A. catechu using HIV NL4.3 in TZM-bl cells based assay

From: Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat

Treatment group      TZM-bl cells (μg/ml)  
*CC50 *IC50 TI
50% Ethanolic extract 371.0 ±11.7 3.6 ± 0.31 103.0 ± 6.3
Aqueous extract >400** 1.8 ± 0.18 >200
n-Butanol fraction >400** 1.7 ± 0.12 >200
  1. *CC 50 : The cytotoxic concentration of the extracts/n-butanol fraction that caused the reduction of viable cells by 50%. All data presented are averages of three independent experiments done in duplicates (mean ± standard error).
  2. *IC 50 : The concentration of the extracts/n-butanol fraction that resulted in 50% inhibition in HIV-1 infection. All data presented are averages of three independent experiments done in duplicates (mean ± standard error).
  3. **CC 50 was not obtained as there was no toxicity up to the maximum concentration tested.
  4. TI: Therapeutic index is CC 50 /IC 50.