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Table 1 Association of host SNPs with treatment response to HCV infection

From: Role of viral and host factors in interferon based therapy of hepatitis C virus infection

Gene symbol

Function

SNP

Effect on interferon therapy

IFN –λ

   

IL-29 (IFN-λ1)

 

rs8099917

TT genotype is favorable

IL-28A (IFN-λ2)

Inhibit viral replication

rs12980275

AA genotype is favorable

IL-28B (IFN-λ3)

 

rs12979860

CC genotype is favorable

IFN - γ

Inhibit viral replication

-768G

Enhances promoter activity 2-3 folds

MBL

Pathogen recognition receptor

O/A at exon 1

X or O mutations linked with non-responsiveness

At promoter region: MBL2*H,Land X,Y.

 

CTLA4

Down regulates T cell functions

-318 C/T

-318C, 49G are favorably linked with therapy response.

IL-10

Anti-inflammatory, Down regulates MHC1and MHC II molecules

-318 C/T

-819T and -592A are positively associated

- 819,

 

- 592

 

IL-18

Pro-inflammatory cytokine

607 C/A,

-607A and -137C are positively associated

Induces IFN-γ

-137 G/C

 

TRAIL

Induces apoptosis in virally infected cells

rs 4242392

Poorly associated

TGFb1

Multifunctional cytokine

codon 10T/C, codon 25G/C

Positively associated

Mx1

Antiviral activities

G/T at nt -88

Positively associated

Osteopontin

Induces Th1 response

nt 443, nt 1748

T/T at nt -443

G/G or G/A at 1748

Positively associated with SVR

LMP7

HLA-1 antigen presentation

LMP7-K

Positively associated with SVR

OAS1

converts ATP into 2'-5' linked oligomers of adenosine

at exon 7 SAS

AA genotype is poorly associated