From: Role of viral and host factors in interferon based therapy of hepatitis C virus infection
Gene symbol | Function | SNP | Effect on interferon therapy |
---|---|---|---|
IFN –λ |  |  |  |
IL-29 (IFN-λ1) |  | rs8099917 | TT genotype is favorable |
IL-28A (IFN-λ2) | Inhibit viral replication | rs12980275 | AA genotype is favorable |
IL-28B (IFN-λ3) |  | rs12979860 | CC genotype is favorable |
IFN - γ | Inhibit viral replication | -768G | Enhances promoter activity 2-3 folds |
MBL | Pathogen recognition receptor | O/A at exon 1 | X or O mutations linked with non-responsiveness |
At promoter region: MBL2*H,Land X,Y. | Â | ||
CTLA4 | Down regulates T cell functions | -318 C/T | -318C, 49G are favorably linked with therapy response. |
IL-10 | Anti-inflammatory, Down regulates MHC1and MHC II molecules | -318 C/T | -819T and -592A are positively associated |
- 819, | Â | ||
- 592 | Â | ||
IL-18 | Pro-inflammatory cytokine | 607 C/A, | -607A and -137C are positively associated |
Induces IFN-γ | -137 G/C |  | |
TRAIL | Induces apoptosis in virally infected cells | rs 4242392 | Poorly associated |
TGFb1 | Multifunctional cytokine | codon 10T/C, codon 25G/C | Positively associated |
Mx1 | Antiviral activities | G/T at nt -88 | Positively associated |
Osteopontin | Induces Th1 response | nt 443, nt 1748 | T/T at nt -443 |
G/G or G/A at 1748 | |||
Positively associated with SVR | |||
LMP7 | HLA-1 antigen presentation | LMP7-K | Positively associated with SVR |
OAS1 | converts ATP into 2'-5' linked oligomers of adenosine | at exon 7 SAS | AA genotype is poorly associated |