Skip to main content
Figure 4 | Virology Journal

Figure 4

From: Differential cellular gene expression in duck trachea infected with a highly or low pathogenic H5N1 avian influenza virus

Figure 4

Analysis of significant differentially expressed genes into pathway. A: in LPAI-H5N1 infected tracheas as compared to mock-infected tracheas, B: in HPAI-H5N1 infected tracheas as compared to mock-infected tracheas, C: in HPAI-H5N1 infected tracheas as compared to LPAI-H5N1 tracheas. The ten most significant pathways are shown in graph A and B, and only the first ten common pathways between HPAI- and LPAI-infection are shown in graph C (dark blue for HPAI-H5N1 and light blue for LPAI-H5N1). The Ingenuity Pathway Analysis software was used to organise significant differentially expressed genes into different signalling pathways in which they are involved and according to the calculated –log (p-values). Data significance is represented by ratio and p-value. Ratios (yellow lines) represent the part of differentially expressed genes from a pathway related to the total number of genes for this same pathway. The p-value is calculated using a right-tailed Fisher’s exact test and corresponds to the probability that the association between genes and a given pathway is not due to random chance. The threshold corresponds to a limit of significance set by the software (p < 0.05).

Back to article page