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Table 3 Genome-wide mutation and selection pressure analysis of Pakistan DENV-3 isolates

From: Evolution and heterogeneity of multiple serotypes of Dengue virus in Pakistan, 2006–2011

Polyprotein position Gene Gene position Wild type Pakistan isolates (n=6) Other reports of similar substitutions Mixed effect model of evolution (MEME) analysis
α β- q- β+ P value Log L
951 NS1 178 L M India 2003–07 [32, 33] & China 2009§ 1.83 0.36 0.99 1844.02 <0.01 −53.95
2063 NS3 590 K R Unique to Pakistan £ 1.28 0 0.98 42.42 0.58 −17.20
2393 NS4B 151 M I India 2003–07 [32, 33] & China 2009§ 1.35 0.16 1.00 0.31 1.00 −9.87
2678 NS5 188 T A India 2003–07 [32, 33], China 2009§, Venezuela 2001-07§, Puerto Rico 2006§ 0.85 0.38 0.99 707.57 0.21 −35.65
3052 NS5 562 Q L India 2003–07 [32, 33], China 2009§, Colombia 2004§ 1.74 1.00 0 2.65 0.64 −33.19
3385 NS5 895 S L Puerto-Rico 2002-03§, Colombia 2003§, Vietnam 2006§ 2.00 0 0.99 35.8 0.47 −21.96
  1. §Directly obtained from the GenBank database.
  2. £Reported in this study.
  3. Mutations under positive selection and those that are unique to Pakistan DENV-3 isolates are shown in bold.