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Table 2 Genome-wide mutation and selection pressure analysis of Pakistan DENV-2 isolates

From: Evolution and heterogeneity of multiple serotypes of Dengue virus in Pakistan, 2006–2011

Polyprotein position Gene Gene position Wild type Post-2008 Pakistan isolates (n=5) Other reports of similar substitutions Mixed effect model of evolution (MEME) analysis
α β- q- β+ P value Log L
130 prM 16 R K Sri Lanka2003-04§ & Pakistan [17] 1.87 0 0.97 91.05 0.15 −35.52
184 prM 70 S A Pakistan£ [17] & Malaysia (sylvatic) [24, 25] 3.61 0 1 134.67 0.05 −41.97
862 NS1 87 T S Sri Lanka2003-04§ 1.25 0 0.97 6.49 0.74 −27.76
1160 NS2A 33 I V India2001-06§ & Sri Lanka 1996-2004§ 0 1 0.06 0.33 0.66 −13.61
1243 NS2A 116 I T Thailand 1984 [26] 0 0 0.6 2.7 0.42 −40.58
2891 NS5 400 T A Sri Lanka 2003-04§ 0 0 0.93 2.85 0.48 −10.8
2953 NS5 462 L I India2001-06§ & Sri Lanka 1996-04§ 1.12 0 0.99 513.74 0.20 −38.62
3107 NS5 616 E G India2001-06§ & Sri Lanka 1996-2004§ 0 1 0.62 0.85 0.44 −9.39
3122 NS5 631 S G India2001-06§ & Sri Lanka 1996-2004§ 0.35 0.45 0.16 1.44 0.23 −32.15
3352 NS5 861 K R Unique to Pakistan £ 0 0 0.98 20.75 0.26 −11.06
3367 NS5 876 N S India2001-06§ & Sri Lanka 1996-04§ 0 0 0.98 19.81 0.19 −11.44
  1. §Directly obtained from the GenBank database.
  2. £Reported in this study.
  3. Mutations under positive selection and those that are unique to Pakistan DENV-2 isolates are shown in bold.