Table 1 The energy contribution of hydrophobic NES residues binding to Φ 1 , Φ 2 , Φ 3 and Φ 4 of CRM1
From: Chikungunya virus capsid protein contains nuclear import and export signals
The binding pocket | Φ1 | Φ2 | Φ3 | Φ4 |
|---|---|---|---|---|
The snurportin-1 residue docking in pocket | L4 | L8 | F12 | V14 |
The snurportin-1 residue’s contribution (Joules) | −20.60 | −20.37 | −23.28 | −16.19 |
The CHIKV CP NES residue docking in pocket | I4 | L9 | L12 | F14 |
The CHIKV-CP NES residue’s contribution (Joules) | −31.52 | −13.21 | −16.50 | −9.34 |