The miRNA world of polyomaviruses

Lagatie, Ole; Tritsmans, Luc; Stuyver, Lieven J

doi:10.1186/1743-422X-10-268

Virology Journal

Table 1 microRNAs in polyomaviruses

From: The miRNA world of polyomaviruses

Virus	miRNAs	miRBase V20 Accession No.	Genomic location (nt position in reference sequence)	mRNA targets	References
JCPyV	jcv-miR-J1-5p	MIMAT0009147	3′ end LTAg (2682–2767 in NC_001699.1)	LTAg, stAg² ULBP3	[63, 65, 66]
JCPyV	jcv-miR-J1-3p	MIMAT0009148	3′ end LTAg (2682–2767 in NC_001699.1)	LTAg, stAg² ULBP3	[63, 65, 66]
BKPyV	bkv-miR-B1-5p	MIMAT0009149	3′ end LTAg (2808–2909 in NC_001538.1)	LTAg, stAg²	[63, 65, 66, 78]
BKPyV	bkv-miR-B1-3p	MIMAT0009150	3′ end LTAg (2808–2909 in NC_001538.1)	LTAg, stAg²	[63, 65, 66, 78]
SV40	sv40-miR-S1-5p	MIMAT0003344	3′ end LTAg (2776–2863 in NC_001669.1)	LT, stAg DMWD², C20orf27²	[64, 85]
SV40	sv40-miR-S1-3p	MIMAT0003345	3′ end LTAg (2776–2863 in NC_001669.1)	LT, stAg DMWD², C20orf27²	[64, 85]
SA12	sa12-miR-S1-5p	n.a.	3′ end LTAg (2786–2869 in NC_007611.1)	LTAg², stAg²	[62]
SA12	sa12-miR-S1-3p	n.a.	3′ end LTAg (2786–2869 in NC_007611.1)	LTAg², stAg²	[62]
MCPyV	mcv-miR-M1-5p	MIMAT0010150	5′ end LTAg (1168–1251 in JN383838.1)	LTAg¹ AMBRA2², RBM9², MECP2², PIK3CD², PSME²3 and RUNX2²	[68, 69]
MCPyV	mcv-miR-M1-3p	MIMAT0010151	5′ end LTAg (1168–1251 in JN383838.1)	LTAg¹ AMBRA2², RBM9², MECP2², PIK3CD², PSME²3 and RUNX2²	[68, 69]
MuPyV	mpv-mir-M1-5p	n.a.	5′ end LTAg (1137–1269 in NC_001515.1)	LTAg, MTAg, stAg	[67]
MuPyV	mpv-mir-M1-3p	n.a.	5′ end LTAg (1137–1269 in NC_001515.1)	LTAg, MTAg, stAg	[67]
BPCV1	Bpcv-mir-B1-3p	MIMAT0020276	between the 3′ ends of the T-antigens and L1/L2 (4917–4987 in NC_010107.1)	T-antigens¹	[72]
BPCV2	Bpcv-mir-B2-3p	MIMAT0020277	between the 3′ ends of the T-antigens and L1/L2 (no reference available)	T-antigens¹	[72]

¹ experimental evidence using reporter constructs only.
² predicted target, no experimental evidence.
n.a. not available.

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ISSN: 1743-422X

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