Table 1 Antiviral activity (IC 50 ) against HCV J6/JFH1-P47, cytotoxicity (CC 50 ) and selectivity index (SI) of Indonesian medicinal plants tested in this study
No. | Botanical name | Parts | Family | IC50a(μg/ml) | CC50(μg/ml) | SI |
|---|---|---|---|---|---|---|
1. | Eupatorium inulifolium | Stems | Asteraceae | > 500 | >500 | nab |
2. | Calliandra polytirsa | Leaves | Fabaceae | 31.9 ± 7.1 | >100 | >3.1 |
3. | Strophacantus membranifolius | Herbs | Acantaceae | >100 | >500 | na |
4. | Cestrum calysinum | Leaves | Solanaceae | 52.1 ± 5.7 | >500 | >9.6 |
5. | Cestrum calysinum | Stems | Solanaceae | >500 | >500 | na |
6. | Eucalyptus globulus | Stems | Myrtaceae | 43.0 ± 39.5 | >100 | >2.3 |
7. | Toona sureni c | Leaves | Meliaceae | 13.9 ± 1.6 | > 500 | >35.9 |
8. | Melicope latifolia c | Leaves | Rutaceae | 3.5 ± 1.4 | >100 | >28.6 |
9. | Melicope latifolia | Stems | Rutaceae | 42.6 ± 37.6 | >100 | >2.4 |
10. | Piper sulcatum | Stems | Piperaceae | 38.0 ± 4.2 | >100 | >2.6 |
11. | Fagraea blumei | Stems | Fagaceae | >100 | >500 | na |
12. | Fraxinus griffithii | Stems | Meliaceae | >500 | >500 | na |
13. | Maesa latifolia | Leaves | Myrsinaceae | 32.7 ± 6.6 | >100 | >3.1 |
14. | Maesa latifolia | Stems | Myrsinaceae | 32.2 ± 10.2 | >100 | >3.1 |
15. | Melanolepis multiglandulosa c | Stems | Euphorbiaceae | 17.1 ± 1.6 | >100 | >5.8 |
16. | Acacia decurens | Leaves | Fabaceae | 44.9 ± 7.1 | >500 | >11.1 |
17. | Randia maculata | Stems | Rubiaceae | 38.7 ± 5.7 | >500 | >12.9 |
18. | Gompostemma polythirsa | Flowers | Acanthaceae | 92.8 ± 19.8 | >500 | >5.4 |
19. | Acmena acuminatissima | Leaves | Myrtaceae | >100 | >100 | na |
20. | Acmena acuminatissima | Stems | Myrtaceae | >100 | >500 | na |
21. | Ficus fistulosa c | Leaves | Moraceae | 15.0 ± 7.1 | >100 | >7.6 |