From: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
Mouse | Time (d.p.i.) | Clinical signs | Mean virus titer (Log10TCID50/g of tissue) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Weight loss (%)a | Ruffled furb | Mortality | BALFc | Lung | Brain | Heart | Liver | Spleen | Kidney | Intestine | |||
1 | 3/10 | 0/10 | 0/10 (0%) | 3.75 (4/6)d | 4.15 (4/6) | - | - | - | - | - | - | ||
2 | 8/10 | 0/10 | 0/10 (0%) | 2.31 (5/6) | 5.69 (5/6) | - | - | - | 1.25 (2/6) | 1.88 (4/6) | - | ||
3 | 9/10 | 7/10 | 0/10 (0%) | 2.75 (6/6) | 4.38 (6/6) | - | - | - | - | - | 0.69 (5/6) | ||
5 | 8/10 | 10/10 | 0/10 (0%) | 3.58 (6/6) | 5.38 (6/6) | - | - | 0.58 (2/6) | - | - | - | ||
7 | 8/10 | 10/10 | 0/10 (0%) | 2.31 (6/6) | 3.69 (6/6) | - | - | - | - | - | - | ||
Ferret | Clinical signs | Euthanized time (d.p.i.) | Virus titer (Log 10 TCID 50 / tissue) | ||||||||||
Weight Loss (%) | Sneezingb | Lethalityc | Trachea | Lung | Brain | Heart | Liver | Spleen | Kidney | Intestine | Olfactory bulb | ||
9/9 (10.7/9.3)e | 9/9 | 0/9 | 3 | 4.92 (2/2)d | 2.59 (2/2) | - | 2.82 (1/2) | - | - | - | - | 5.41 (2/2) | |
7 | 4.11 (2/2) | 2.87 (2/2) | - | - | 2.16 (1/2) | - | - | - | - |