Figure 6

Cytotoxicity of combined radiation and AP27i145 HSV-1 treatment. (a) A549, (b)) H460, (c) H838, and (d) H1975 lung cancer cells were treated with AP27i145 or 5dl1.2 HSV-1 at an MOI of 0.01. Culture medium alone was used for mock infection. Cells were subsequently treated with radiation at 0, 2, 4, or 8 Gy 48 h after infection. On day 3 after irradiation, 3 cultures for each combination treatment were counted for viable cells. The results are expressed as a percentage of the mock-infected and mock-irradiated cells (survival ratio). Data are expressed as means ± SE.