Figure 1
From: Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways
Schematic of novel bicistronic LVs encoding rHER-2 and survival factors. Illustration of self-inactivating (SIN) lentiviral transfer vectors. Map highlights essential vector elements; survival factors include: c-FLIPS, c-FLIPL, Bcl-XL, M11L, and AKT-1. Expression of proteins of interest is driven by the constitutive promoter, EF-1α. The IRES from the EMCV enables the expression of the secondary cDNA encoding the survival factors.