Vaccination of ferrets with a recombinant G glycoprotein subunit vaccine provides protection against Nipah virus disease for over 12 months

Table 1 Study 1: Genome detection in ferrets challenged at day 20 post vaccination

Ferret# - dose HeVsG	Ab titre to NiV at challenge	Eut dpc	Genome detected by PCR (dpc)						Virus positive tissues
Ferret# - dose HeVsG	Ab titre to NiV at challenge	Eut dpc	Oral swab	Rectal swab	Blood	Nasal wash	Urine	Tissues	Virus positive tissues
1-0	<2	6	PM	PM	PM	PM	PM	13/13	8/13
2-0	<2	10	6, 8, PM	8, PM	8, PM	8, PM	PM	13/13	6/13
3-4	64, 64	21	-	-	-	-	-	0/13	ND
4-4	NC	na	NC	NC	NC	NC	NC	NC	ND
5-20	256, 256	21	-	-	-	-	-	0/13	ND
6-20	256, 512	21	-	-	-	-	-	0/13	ND
7-100	NC	na	NC	NC	NC	NC	NC	NC	ND
8-100	256, 512	21	-	-	-	-	-	0/13	ND

Ab antibody, Eut dpc day post challenge that ferrets were euthanized PM post mortem, NC no challenge, ND not done; -, no viral RNA detected, na not applicable.

ISSN: 1743-422X