Figure 3
From: The N-end rule and retroviral infection: no effect on integrase
Kinetics and nuclear localization of proviral DNA in N-recognin deficient cells. UBR1−/− UBR2−/− Luci RNAi (control) and UBR1−/− UBR2−/−UBR4 RNAi cells were infected with VSVG pseudotyped HIV-1-EGFP at an MOI of 1. Viral cDNA products were quantified by qPCR at indicated times. (A) First jump products. The data are expressed as relative to the control 4 hr time point. (B) 2LTR circles. The data are expressed as relative to the control 24 hr time point. The data for the UBR1−/− UBR2−/−UBR4RNAi are the average of UBR1−/− UBR2−/−UBR4KD1 and UBR1−/− UBR2−/−UBR4KD2 cells.