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Table 3 Piscine reovirus (PRV) genome coding assignments and protein characteristics

From: Whole-genome analysis of piscine reovirus (PRV) shows PRV represents a new genus in family Reoviridae and its genome segment S1 sequences group it into two separate sub-genotypes

Genome segment* Molecular size (bp)** 5′UTR (bp)** 3′UTR (bp)** Protein name*** Protein size (aa) & mass (kDa)1 pI value Predicted function
L1 3911 18 44 Core shell (T = 1) [λ1] 1282, 141.41 kDa 5.47 major inner capsid protein, Helicase, RNA triphosphatase
L2 3935 18 44 Core turret [λ2] 1290, 143.75 kDa 4.81 core spike, guanylyl transferase
L3 3916 7 48 Core RdRp [λ3] 1286, 144.24 kDa 8.68 minor inner capsid protein, RNA polymerase
M1 2383 21 79 Core NTPase [μ2] 760, 86.09 kDa 8.23 minor inner capsid protein, nucleoside triphosphate phosphohydrolase
M2 2179 26 89 Outer shell (T = 13) [μ1] 687, 74.26 kDa 6.27 outer capsid protein, membrane penetration, apoptosis
M3 2403 83 61 NS factory [μNS] 752, 83.53 kDa 5.00 NS, genome packaging?
S1 1081 28 60 Outer clamp [σ3] 330, 37.08 kDa 7.43 major outer capsid protein, dsRNA binding protein, translation control, modulation of cellular interferon, zinc-binding
NS, p13 [σ1s] 124, 12.99 kDa 4.88 NS, block cell-cycle progression, cytolytic in PRV
S2 1329 21 45 Core clamp [σ2] 420, 45.93 kDa 9.02 major inner capsid protein, morphogenesis?
S3 1143 28 50 NS RNA [σNS] 354, 39.07 kDa 7.76 NS, genome packaging?
S4 1040 38 54 Outer fiber [σ1] 315, 34.60 kDa 6.04 outer capsid protein (virus attachment), cell tropism, pathways of viral spread in-vivo, virulence
  1. *Genome segment nomenclature used by Palacio et al.[2] for PRV.
  2. **Values obtained from cDNA sequenced [2; this paper PRV strain 358]. The 3′UTR does not include the stop codon.
  3. ***Protein nomenclature used by Key et al.[10] for PRV. Homolog of Mammalian reovirus protein is given in square brackets.
  4. 1PRV gene products are calculated from sequence data [2; this paper PRV strain 358].