Days post-infection | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Tissue | Cytokine | Sham-infected | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Serum | IL-4 | 9 ± 8 | nd | nd | < 4a | 26 ± 15 | 38 ± 7 | 27 ± 7 | 41 ± 24 | 44 ± 16 |
IL-6 | 103 ± 75 | nd | nd | 95 ± 73 | 516 ± 450 | 605 ± 192 | 438 ± 119 | 1927 ± 1431 | 3362 ± 3163 | |
IL-10 | 12 ± 7 | nd | nd | 91 ± 22 | 106 ± 10 | 111 ± 60 | 172 ± 29 | 1110 ± 1055 | 598 ± 500 | |
IL-17 | 10 ± 3 | nd | nd | 28 ± 1 | 38 ± 19 | 34 ± 2 | 46 ± 20 | 129 ± 88 | 68 ± 27* | |
MCP-1 | 81 ± 65 | nd | nd | 65 ± 8 | 733 ± 467 | 749 ± 129 | 688 ± 255 | 1257 ± 419** | 1590 ± 665*** | |
TNF-α | 35 ± 10 | nd | nd | < 7a | 12 ± 7 | 57 ± 8 | 79 ± 32 | 165 ± 59 | 244 ± 136* | |
MIP-1α | 52 ± 49 | nd | nd | < 2a | 24 ± 18 | 28 ± 22 | 593 ± 493 | 1023 ± 613 | 1041 ± 770 | |
GM-CSF | 30 ± 9 | nd | nd | 91 ± 22 | 95 ± 24 | 178 ± 121 | 147 ± 81 | 350 ± 292 | 371 ± 173 | |
RANTES | 52 ± 17 | nd | nd | 55 ± 13 | 89 ± 4 | 137 ± 56 | 172 ± 98 | 402 ± 129** | 520 ± 193*** | |
Brain | IL-6 | 306 ± 216 | nd | nd | 206 ± 8 | 168 ± 51 | 446 ± 92 | 150 ± 102 | 848 ± 725 | 516 ± 224 |
MCP-1 | 198 ± 76 | nd | nd | 90 ± 34 | 83 ± 1 | 313 ± 171 | 211 ± 17 | 1703 ± 1491 | 2538 ± 1315 | |
Liver | IL-1α | 1513 ± 430 | 1915 ± 575 | 1841 ± 591 | 3398 ± 667 | 3066 ± 390 | 3293 ± 1234 | 5436 ± 2061 | 13500 ± 2089** | ndc |
IL-1β | 8415 ± 3244 | 4859 ± 1427 | 4906 ± 1664 | 19130 ± 4061 | 17366 ± 678 | 15160 ± 4928 | 16980 ± 4176 | 54765 ± 8595** | ndc | |
IL-10 | 759 ± 239 | 1457 ± 627 | 1425 ± 542 | 1918 ± 329 | 1569 ± 4 | 1694 ± 428 | 1112 ± 387 | 5010 ± 1110*** | ndc | |
IL-17 | 728 ± 429 | 871 ± 275 | 855 ± 344 | 1864 ± 383 | 1486 ± 135 | 1065 ± 373 | 1347 ± 681 | 15409 ± 4366*** | ndc | |
MCP-1 | 842 ± 298 | 913 ± 755 | 955 ± 725 | 6879 ± 1464** | 5426 ± 446* | 3326 ± 916 | 3752 ± 1714 | 12370 ± 3673*** | ndc | |
GM-CSF | 2009 ± 812 | 2490 ± 976 | 2494 ± 993 | 4125 ± 980 | 3342 ± 131 | 2556 ± 937 | 3316 ± 1598 | 25400 ± 926*** | ndc | |
MIP-1α | 2630 ± 867 | 2464 ± 778 | 2276 ± 1102 | 834 ± 60 | 837 ± 46 | 3924 ± 1113 | 12205 ± 10866 | 80191 ± 17917*** | ndc | |
Lung | IL-1α | 447 ± 134 | nd | nd | 914 ± 332 | 518 ± 2 | 1020 ± 341 | 632 ± 90 | 1590 ± 1620 | 9510 ± 7262* |
IL-2 | 393 ± 38 | nd | nd | 490 ± 8 | 633 ± 15 | 1690 ± 452 | 2000 ± 632 | 3012 ± 1502 | 8423 ± 7650 | |
IL-3 | 392 ± 101 | nd | nd | 334 ± 36 | 364 ± 138 | 355 ± 104 | 279 ± 45 | 407 ± 126 | 2403 ± 101** | |
IL-4 | 401 ± 128 | nd | nd | 493 ± 286 | 328 ± 242 | 786 ± 156 | 486 ± 94 | 868 ± 411 | 3914 ± 2030** | |
IL-5 | 777 ± 110 | nd | nd | 609 ± 335 | 590 ± 30 | 1361 ± 273 | 891 ± 221 | 2033 ± 1246 | 5604 ± 2536*** | |
IL-6 | 500 ± 216 | nd | nd | 276 ± 345 | 995 ± 314 | 998 ± 198 | 1490 ± 1130 | 2059 ± 815 | 6680 ± 4214 | |
IL-10 | 266 ± 24 | nd | nd | < 6b | 194 ± 235 | 445 ± 165 | 1110 ± 942 | 1620 ± 1511 | 2340 ± 1174 | |
IL-12 | 613 ± 270 | nd | nd | 129 ± 153 | 528 ± 568 | 751 ± 256 | 485 ± 132 | 704 ± 218 | 3348 ± 1584** | |
MCP-1 | 338 ± 74 | nd | nd | 543 ± 38 | 1590 ± 245 | 1506 ± 148 | 1379 ± 355 | 3988 ± 3930 | 23780 ± 23492 | |
TNF-α | 243 ± 200 | nd | nd | 336 ± 465 | 186 ± 40 | 705 ± 341 | 345 ± 93 | 1358 ± 1250 | 8622 ± 4184** | |
MIP-1α | 565 ± 216 | nd | nd | < 8b | < 8b | 1505 ± 148 | 1379 ± 355 | 3988 ± 3929 | 23781 ± 23492 | |
RANTES | 393 ± 38 | nd | nd | 490 ± 8 | 633 ± 15 | 1690 ± 452 | 2000 ± 632 | 3012 ± 1502 | 8423 ± 7650 | |
Spleen | IL-1β | 5166 ± 2212 | 20596 ± 1045 | 35663 ± 16622* | 16470 ± 7867 | 72114 ± 20013*** | 71460 ± 25186*** | 17603 ± 4578 | 17558 ± 7660 | 15264 ± 15228 |
IL-2 | 302 ± 60 | 1094 ± 377 | 1907 ± 871 | 1428 ± 745 | 925 ± 413 | 9384 ± 1767*** | 2418 ± 1912 | 471 ± 136 | 668 ± 296 | |
IL-6 | 937 ± 891 | 315 ± 206 | 3932 ± 1552 | 7512 ± 4901 | 8855 ± 8640 | 11803 ± 10907 | 11662 ± 7191 | 10277 ± 15901 | 7872 ± 6471 | |
IL-10 | 359 ± 181 | 555 ± 427 | 2513 ± 1028 | 9723 ± 6700 | 2933 ± 3526 | 34446 ± 12413*** | 10644 ± 11632 | 974 ± 475 | 10010 ± 3066 | |
MCP-1 | 65 ± 174 | 1774 ± 734 | 3186 ± 1247 | 2686 ± 1874 | 10124 ± 2102 | 8822 ± 6241 | 10004 ± 6407 | 11378 ± 8843 | 37106 ± 34700** | |
MIP-1α | 2460 ± 1335 | 3439 ± 457 | 10489 ± 6500 | 21290 ± 14825 | 50613 ± 23941 | 46596 ± 3376 | 79600 ± 40143 | 174281 ± 161060 | 221110 ± 206073* |