Necrotizing myositis causes restrictive hypoventilation in a mouse model for human enterovirus 71 infection

Table 1 The muscle tropism of four clinical isolated EV71 strains

Strain		FY0805	JK2009	BZ200805	MZ2008
Accession number		HQ882182	HQ694982	HQ694983	HQ694985
Log^TCID50/ml supernatant
RD cell	0 h	0	0	0	0
	36 h	6.63 ± 0.35^a	6.27 ± 0.24	6.04 ± 0.42	6.88 ± 0.27
	72 h	7.97 ± 0.46	7.83 ± 0.34	7.87 ± 0.25	8.38 ± 0.36
SHSY5Y cell	0 h	0	0	0	0
	36 h	0	0	0	0
	72 h	0	0	0	0
Log^{Viral RNA copies}/mg tissue
Skeletal muscle of ICR mice	3 d.p.i	4.02 ± 0.18	4.32 ± 0.27	4.75 ± 0.33	4.32 ± 0.27
Skeletal muscle of ICR mice	5 d.p.i	3.87 ± 0.22	4.06 ± 0.19	4.18 ± 0.20	4.06 ± 0.19
Brain of ICR mice	3 d.p.i	1.02 ± 0.12	0.37 ± 0.12	1.19 ± 0.17	1.16 ± 0.11
Brain of ICR mice	5 d.p.i	0.87 ± 0.04	0.24 ± 0.09	1.05 ± 0.23	0.98 ± 0.26

ISSN: 1743-422X