Inhibition of hepatitis B virus (HBV) gene expression and replication by HBx gene silencing in a hydrodynamic injection mouse model with a new clone of HBV genotype B

Table 2 HBsAg detection in HBxi285 treated and control mice

Mouse group	Persistent negative	Negative → positive^a	Persistent positive or positive → negative^b
pSR-HBxi285	7/ 10	2/ 10	1/ 10
pSB-HBxi285	3/ 10	4/ 10	3/ 10
pSR-HBxicon	3/ 10	0/ 10	7/ 10
pSR vector	1/ 10	0/ 10	9/ 10

^a Those mice with initial negative HBsAg became HBsAg positive. ^b Those mice with initial positive HBsAg became HBsAg negative during the whole experimental period of 16 weeks after HI. The cutoff value for determining HBsAg-positivity was 0.1.

ISSN: 1743-422X