Table 1 The characteristics of the studied patients at the occurrence of biochemical breakthrough
Characteristics | Weeks of biochemical breakthrough | ||
|---|---|---|---|
≤24 (n=43) | >24 (n=7) | p value | |
Age, yrs | 32.5±7.9 | 37.1±5.8 | NS |
Men, n(%) | 30(69.8%) | 6(85.7%) | NS |
Duration of previous LAM | 126±43 | 134±37 | NS |
treatment (weeks) | (104–312) | (104–208) | |
ALT level, n(%) | |||
2-3×ULN | 21(48.8%) | 1(14.3%) | NS |
≥3×ULN | 22(51.2%) | 6(85.7%) | |
ALT level,IU/L | 190±126 | 318±172 | 0.024 |
HBV DNA ≥1×107 copies/mL,% | 29(67.4%) | 6(85.7%) | NS |
HBV DNA(log10 copies/mL) | 7.3±0.8 | 7.7±0.9 | NS |
HBV genotype, n (%) | |||
B | 30(69.8%) | 5(71.4%) | NS |
C | 12(27.9%) | 2(28.6%) | |
B and C | 1( 2.3%) | 0(0) | |