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Table 3 Sequence comparison of the P1 region of A24 Cruzeiro and A-SIRs

From: Examination of soluble integrin resistant mutants of foot-and-mouth disease virus

Gene

A24 Cruzeiro WT

A-SIR #15 and #23 (Class I)

A-SIR #42 and #45 (Class II)

 

Nucleotidea

Codonb

Amino acidc

Nucleotidea

Codonb

Amino acidc

Nucleotidea

Codonb

Amino acidc

VP2

C50

cgG

----

----

----

----

G5045

cgA

Silent

VP1

G6

acG

----

C6

acC

Silent

C6

acC

Silent

VP1

G283

Gaa

E95

----

----

----

A28342

Aaa

K95

VP1

C287

tCa

S96

----

----

----

T28742

tTa

L96

VP1

G434

gGc

G145

A434

gAc

D145

----

----

----

VP1

T449

cTc

L150

----

----

----

C44942

cCc42

P15042

       

G44945

cGc45

R15045

VP1

T461

gTc

V154

C46123

gCc

A15423

----

----

----

  1. a Nucleotide differences between viruses followed by number indicating its position within the gene coding sequence.
  2. b Lowercase letters indicate bases shared by the 2 viruses and capital letters indicate bases differing between the viruses.
  3. c One-letter code of the encoded amino acid residues followed by number indicating residue position in the polypeptide.
  4. P1 region of A24 Cruzeiro (Accession # AY596768) was compared against: Class I (#15 and #23) and Class II (#42 and #45) A-SIRs. Nucleotide changes relative to WT were indicated and codon positions. Silent mutations and amino acid substitutions are indicated. A-SIR mutant numerical designations were superscripted.