Figure 1

In silico analysis of the HPyV unique peptide sequences as compared to the human proteome. a. The polyomavirus proteome was presented as 17,396 pentapeptides, 17,347 hexapeptides, and 17,304 heptapeptides to the complete human proteome. The number of polyomavirus peptides with zero up to 30 matches in the human genome are given, with values for hexa- and hepta-peptides numbers on the primary Y-axis (left), while values for pentapeptides are shown on the secondary Y-axis (right). b. Percentage of HPyV penta-peptides with no match in the human proteome. The number of “zero hit” pentapeptides was divided by the total number of amino acids for each viral protein (protein length differ between viral species). Each data-cluster contains 11 data-points, corresponding to the following viruses: JCV (□, n = 134 unique pentapeptides), BKV (○, n = 155), SV40 (n = 150), KIV (△, n = 155), WUV (▽, n = 121), MCV (&z.diam;, n = 147), MWV (✖, n = 150), TSV (n = 160), HPyV6 (✚, n = 148), HPyV7 (❋, n = 156), and HPyV9 (◗, n = 133). The means (16.6%; 9.3%; 7.8%; and 6.2%; respectively) with standard deviations are shown.