Skip to main content
Figure 4 | Virology Journal

Figure 4

From: Intranasal immunization with a helper-dependent adenoviral vector expressing the codon-optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice

Figure 4

Duration of the immune responses stimulated by single intranasal administration of HDAd-Fsyn in BALB/c mice. Six BALB/c mice were immunized intranasally with one dose of HDAd-Fsyn in week 0. *P<0.05; ***P<0.0001. Values represent mean ± SEM. (A) Serum anti-RSV F IgG induced by HDAd-Fsyn. RSV F-specific antibody titers were measured by ELISA at 2-week intervals up to 14 weeks after immunization. The results represent log10 endpoint values for six individual mice. (B) Virus-neutralizing activity in sera from mice immunized with HDAd-Fsyn. Virus-neutralizing titers in sera were measured by immunoenzyme assay at 2-week intervals up to 14 weeks after immunization. Results are expressed as neutralizing titers corresponding to the serum dilution giving 50% inhibition of plaque formation.

Back to article page

Virology Journal

ISSN: 1743-422X